Thum - Verhaltensneurogenetik

2023

• The adhesion G protein-coupled receptor CG11318/mayo controls midgut development in Drosophila
  Vieira-Contreras F*, Auger GM*, Müller L, Richter V, Huetteroth W, Seufert F, Hildebrand PW, Scholz N, Thum AS, Ljaschenko D, Blanco-Redondo B, Langenhan T.
  Cell Reports 2023, accepted.
• Four Individually Identified Paired Dopamine Neurons Signal Taste Punishment in Larval Drosophila
  Weber D, Vogt K, Miroschnikow A, Pankratz M, Thum AS.
  eLife 2023. 12:RP91387.
  DOI: 10.7554/eLife.91387.1
• Morphology and ultrastructure of external sense organs of Drosophila larvae
  Richter V, Rist A, Kislinger G, Laumann M, Schoofs A, Miroschnikow A, Pankratz M, Cardona A, Thum AS.
  eLife 2023 12:RP91155.
  DOI: 10.7554/eLife.91155.1
• Rewarding Capacity of Optogenetically Activating a Giant GABAergic Central-Brain Interneuron in Larval Drosophila
  Mancini N, Thoener J, Tafani E, Pauls D, Mayseless O, Strauch M, Eichler K, Champion A, Kobler O, Weber D, Sen E, Weiglein A, Hartenstein V, Chytoudis-Peroudis CC, Jovanic T, Thum AS, Rohwedder A, Schleyer M, Gerber B.
  J Neurosci. 2023 Nov 1;43(44).
  DOI: 10.1523/JNEUROSCI.2310-22.2023
• Developmental emergence of sleep rhythms enables long-term memory in Drosophila
  Poe AR, Zhu L, Szuperak M, McClanahan PD, Anafi RC, Scholl B, Thum AS, Cavanaugh DJ, Kayser MS.
  Sci Adv. 2023 Sep 8;9(36).
  DOI: 10.1126/sciadv.adh2301
• The making of a maggot brain.
  Thum AS, Gerber B.
  Elife. 2023 Mar 3;12:e86696.
  DOI: 10.7554/eLife.86696
• The Analysis of Aversive Olfactory-Taste Learning and Memory in Drosophila Larvae
  Weber D, Richter V, Rohwedder A, Großjohann A, Thum AS.
  Cold Spring Harb Protoc. 2023 Mar 1;2023(3).
  DOI: 10.1101/pdb.prot108050
• Learning and Memory in Drosophila Larvae
  Weber D, Richter V, Rohwedder A, Großjohann A, Thum AS.
  Cold Spring Harb Protoc. 2023 Mar 1;2023(3).
  DOI: 10.1101/pdb.top107863


•  

2020 - 2022

• Synchronous and opponent thermosensors use flexible cross-inhibition to orchestrate thermal homeostasis
  Hernandez-Nunez L, Chen A, Budelli G, Berck ME, Richter V, Rist A, Thum AS, Cardona A, Klein M, Garrity P, Samuel ADT.
  Sci Adv. 2021 Aug 27;7(35).
  DOI: 10.1126/sciadv.abg6707
• Ethanol-guided behavior in Drosophila larvae
  Schumann I, Berger M, Nowag N, Schäfer Y, Saumweber J, Scholz H, Thum AS.
  Sci Rep. 2021 Jun 10;11:12307.
  DOI: 10.1038/s41598-021-91677-3
• The Panopticon - assessing the effect of starvation on prolonged fly activity and place preference
  Mahishi D*, Triphan T*, Hesse R, Huetteroth W.
  Front Behav Neurosci. 2021 Mar 25;15:46.
  DOI: 10.3389/fnbeh.2021.64014
• The PEDtracker: An Automatic Staging Approach for Drosophila melanogaster Larvae
  Schumann I, Triphan T.
  Front Behav Neurosci. 2020 Dec 16;14:612313.
  DOI: 10.3389/fnbeh.2020.612313
• Controlling the behaviour of Drosophila melanogaster via smartphone optogenetics
  Meloni I, Sachidanandan D, Thum AS, Kittel RJ, Murawski C.
  Sci Rep. 2020 Oct 19;10(1):17614.
  DOI: 10.1038/s41598-020-74448-4
• Identification of Dopaminergic Neurons That Can Both Establish Associative Memory and Acutely Terminate Its Behavioral Expression
  Schleyer M, Weiglein A, Thoener J, Strauch M, Hartenstein V, Kantar Weigelt M, Schuller S, Saumweber T, Eichler K, Rohwedder A, Merhof D, Zlatic M, Thum AS, Gerber B.
  J Neurosci. 2020 Jul 29;40(31):5990-6006.
  DOI: 10.1523/JNEUROSCI.0290-20.2020
• Recurrent architecture for adaptive regulation of learning in the insect brain
  Eschbach C, Fushiki A, Winding M, Schneider-Mizell CM, Shao M, Arruda R, Eichler K, Valdes-Aleman J, Ohyama T, Thum AS, Gerber B, Fetter RD, Truman JW, Litwin-Kumar A, Cardona A, Zlatic M.
  Nat Neurosci. 2020 Apr;23(4):544-555.
  DOI: 10.1038/s41593-020-0607-9
• Food restriction reconfigures naïve and learned choice behavior in Drosophila larvae
  Brünner B, Saumweber J, Samur M, Weber D, Schumann I, Mahishi D, Rohwedder A, Thum AS.
  J Neurogenet. 2020 Mar;34(1):123-132.
  DOI: 10.1080/01677063.2020.1714612

2015 – 2019

• Reversal learning in Drosophila larvae
  Mancini N, Hranova S, Weber J, Weiglein A, Schleyer M, Weber D, Thum AS, Gerber B.
  Learn Mem. 2019 Oct 15;26(11):424-435.
  DOI: 10.1101/lm.049510.119

• MEK inhibitor cobimetinib rescues a dRaf mutant lethal phenotype in Drosophila melanogaster
  Pfeifle I, Bohnekamp J, Volkhardt A, Kirsten H, Rohwedder A, Thum A, Magin TM, Kunz M.
  Exp Dermatol. 2019 Sep;28(9):1079-1082.
  DOI: 10.1111/exd.14010

• Reward signaling in a recurrent circuit of dopaminergic neurons and peptidergic Kenyon cells
  Lyutova R, Selcho M, Pfeuffer M, Segebarth D, Habenstein J, Rohwedder A, Frantzmann F, Wegener C, Thum AS, Pauls D.
  Nat Commun. 2019 Jul 15;10(1):3097.
  DOI: 10.1038/s41467-019-11092-1

• Placental epigenetics for evaluation of fetal congenital heart defects: Ventricular Septal Defect (VSD)
  Radhakrishna U, Albayrak S, Zafra R, Baraa A, Vishweswaraiah S, Veerappa AM, Mahishi D, Saiyed N, Mishra NK, Guda C, Ali-Fehmi R, Bahado-Singh RO.
  PLoS One. 2019 Mar 21;14(3):e0200229.
  DOI: 10.1371/journal.pone.0200229

• Connectomics: Arrested Development
  Triphan T, Thum AS.
  Curr Biol. 2019 Feb 4;29(3):R90-R92.
  DOI: 10.1016/j.cub.2018.11.069

• Drosophila melanogaster cloak their eggs with pheromones, which prevents cannibalism
  Narasimha S, Nagornov KO, Menin L, Mucciolo A, Rohwedder A, Humbel BM, Stevens M, Thum AS, Tsybin YO, Vijendravarma RK.
  PLoS Biol. 2019 Jan 10;17(1):e2006012.
  DOI: 10.1371/journal.pbio.2006012

• Connectomics and function of a memory network: the mushroom body of larval Drosophila
  Thum AS, Gerber B.
  Curr Opin Neurobiol. 2019 Feb;54:146-154.
  DOI: 10.1016/j.conb.2018.10.007

• Halloween genes in panarthropods and the evolution of the early moulting pathway in Ecdysozoa
  Schumann I, Kenny N, Hui J, Hering L, Mayer G.
  R Soc Open Sci. 2018 Sep 12;5(9):180888.
  DOI: 10.1098/rsos.180888

• Maggot Instructor: Semi-Automated Analysis of Learning and Memory in Drosophila Larvae
  Tomasiunaite U, Widmann A, Thum AS.
  Front Psychol. 2018 Jun 20;9:1010.
  DOI: 10.3389/fpsyg.2018.01010

• Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila
  Saumweber T, Rohwedder A, Schleyer M, Eichler K, Chen YC, Aso Y, Cardona A, Eschbach C, Kobler O, Voigt A, Durairaja A, Mancini N, Zlatic M, Truman JW, Thum AS, Gerber B.
  Nat Commun. 2018 Mar 16;9(1):1104.
  DOI: 10.1038/s41467-018-03130-1

• Brassinosteroids Dominate Hormonal Regulation of Plant Thermomorphogenesis via BZR1
  Ibañez C, Delker C, Martinez C, Bürstenbinder K, Janitza P, Lippmann R, Ludwig W, Sun H, James GV, Klecker M, Grossjohann A, Schneeberger K, Prat S, Quint M.
  Curr Biol. 2018 Jan 22;28(2):303-310.e3.
  DOI: 10.1016/j.cub.2017.11.077

• larvalign: Aligning Gene Expression Patterns from the Larval Brain of Drosophila melanogaster
  Muenzing SEA, Strauch M, Truman JW, Bühler K, Thum AS, Merhof D.
  Neuroinformatics. 2018 Jan;16(1):65-80.
  DOI: 10.1007/s12021-017-9349-6

• Odor-taste learning in Drosophila larvae
  Widmann A, Eichler K, Selcho M, Thum AS, Pauls D.
  J Insect Physiol. 2018 Apr;106(Pt 1):47-54.
  DOI: 10.1016/j.jinsphys.2017.08.004

• A map of sensilla and neurons in the taste system of drosophila larvae.
  Rist A, Thum AS.
  J Comp Neurol. 2017 Dec 15;525(18):3865-3889.
  DOI: 10.1002/cne.24308

• The complete connectome of a learning and memory centre in an insect brain.
  Eichler K, Li F, Litwin-Kumar A, Park Y, Andrade I, Schneider-Mizell CM, Saumweber T, Huser A, Eschbach C, Gerber B, Fetter RD, Truman JW, Priebe CE, Abbott LF, Thum AS, Zlatic M, Cardona A.
  Nature. 2017 Aug 9;548(7666):175-182.
  DOI: 10.1038/nature23455

• Anatomy and behavioral function of serotonin receptors in Drosophila melanogaster larvae.
  Huser A, Eschment M, Güllü N, Collins KAN, Böpple K, Pankevych L, Rolsing E, Thum AS.
  PLoS One. 2017 Aug 4;12(8):e0181865.
  DOI: 10.1371/journal.pone.0181865

• The Ol1mpiad: concordance of behavioural faculties of stage 1 and stage 3 Drosophila larvae.
  Almeida-Carvalho MJ, Berh D, Braun A, Chen YC, Eichler K, Eschbach C, Fritsch PMJ, Gerber B, Hoyer N, Jiang X, Kleber J, Klämbt C, König C, Louis M, Michels B, Miroschnikow A, Mirth C, Miura D, Niewalda T, Otto N, Paisios E, Pankratz MJ, Petersen M, Ramsperger N, Randel N, Risse B, Saumweber T, Schlegel P, Schleyer M, Soba P, Sprecher SG, Tanimura T, Thum AS, Toshima N, Truman JW, Yarali A, Zlatic M.
  J Exp Biol. 2017 Jul 1;220(Pt 13):2452-2475.
  DOI: 10.1242/jeb.156646

• Genetic Dissection of Aversive Associative Olfactory Learning and Memory in Drosophila Larvae
  Widmann A, Artinger M, Biesinger L, Boepple K, Peters C, Schlechter J, Selcho M, Thum AS.
  PLoS Genet. 2016 Oct 21;12(10):e1006378.
  DOI: 10.1371/journal.pgen.1006378

• Caffeine Taste Signaling in Drosophila Larvae
  Apostolopoulou AA, Köhn S, Stehle B, Lutz M, Wüst A, Mazija L, Rist A, Galizia CG, Lüdke A, Thum AS.
  Front Cell Neurosci. 2016 Aug 9;10:193.
  DOI: 10.3389/fncel.2016.00193

• Immunolocalization of Arthropsin in the Onychophoran Euperipatoides rowelli (Peripatopsidae)
  Schumann I, Hering L, Mayer G.
  Front Neuroanat. 2016 Aug 4;10:80.
  DOI: 10.3389/fnana.2016.00080

• Four Individually Identified Paired Dopamine Neurons Signal Reward in Larval Drosophila
  Rohwedder A, Wenz NL, Stehle B, Huser A, Yamagata N, Zlatic M, Truman JW, Tanimoto H, Saumweber T, Gerber B, Thum AS.
  Curr Biol. 2016 Mar 7;26(5):661-9.
  DOI: 10.1016/j.cub.2016.01.012

• Taste processing in Drosophila larvae
  Apostolopoulou AA, Rist A, Thum AS.
  Front Integr Neurosci. 2015 Oct 13;9:50.
  DOI: 10.3389/fnint.2015.00050

• Neuropeptide F neurons modulate sugar reward during associative olfactory learning of Drosophila larvae
  Rohwedder A, Selcho M, Chassot B, Thum AS.
  J Comp Neurol. 2015 Dec 15;523(18):2637-64.
  DOI: 10.1002/cne.23873

• Phylogenetic analysis and expression patterns of Pax genes in the onychophoran Euperipatoides rowelli reveal a novel bilaterian Pax subfamily
  Franke FA, Schumann I, Hering L, Mayer G.
  Evol Dev. 2015 Jan-Feb;17(1):3-20.
  DOI: 10.1111/ede.12110

2010 – 2014

• Characterization of the octopaminergic and tyraminergic neurons in the central brain of Drosophila larvae
  Selcho M, Pauls D, Huser A, Stocker RF, Thum AS.
  J Comp Neurol. 2014 Oct 15;522(15):3485-500.
  DOI: 10.1002/cne.23616

• Composition of agarose substrate affects behavioral output of Drosophila larvae
  Apostolopoulou AA, Hersperger F, Mazija L, Widmann A, Wüst A, Thum AS.
  Front Behav Neurosci. 2014 Jan 28;8:11.
  DOI: 10.3389/fnbeh.2014.00011

• The neuronal and molecular basis of quinine-dependent bitter taste signaling in Drosophila larvae
  Apostolopoulou AA, Mazija L, Wüst A, Thum AS.
  Front Behav Neurosci. 2014 Jan 27;8:6.
  DOI: 10.3389/fnbeh.2014.00006

• Mushroom body miscellanea: transgenic Drosophila strains expressing anatomical and physiological sensor proteins in Kenyon cells
  Pech U, Dipt S, Barth J, Singh P, Jauch M, Thum AS, Fiala A, Riemensperger T.
  Front Neural Circuits. 2013 Sep 23;7:147.
  DOI: 10.3389/fncir.2013.00147

• Maggot learning and Synapsin function
  Diegelmann S, Klagges B, Michels B, Schleyer M, Gerber B.
  J Exp Biol. 2013 Mar 15;216(Pt 6):939-51.
  DOI: 10.1242/jeb.076208

• Appetitive associative olfactory learning in Drosophila larvae
  Apostolopoulou AA, Widmann A, Rohwedder A, Pfitzenmaier JE, Thum AS.
  J Vis Exp. 2013 Feb 18;(72):4334.
  DOI: 10.3791/4334

• Consolidated and labile odor memory are separately encoded within the Drosophila brain
  Scheunemann L, Jost E, Richlitzki A, Day JP, Sebastian S, Thum AS, Efetova M, Davies SA, Schwärzel M.
  J Neurosci. 2012 Nov 28;32(48):17163-71.
  DOI: 10.1523/JNEUROSCI.3286-12.2012

• The serotonergic central nervous system of the Drosophila larva: anatomy and behavioral function
  Huser A, Rohwedder A, Apostolopoulou AA, Widmann A, Pfitzenmaier JE, Maiolo EM, Selcho M, Pauls D, von Essen A, Gupta T, Sprecher SG, Birman S, Riemensperger T, Stocker RF, Thum AS.
  PLoS One. 2012;7(10):e47518.
  DOI: 10.1371/journal.pone.0047518

• Nutritional value-dependent and nutritional value-independent effects on Drosophila melanogaster larval behavior
  Rohwedder A, Pfitzenmaier JE, Ramsperger N, Apostolopoulou AA, Widmann A, Thum AS.
  Chem Senses. 2012 Oct;37(8):711-21.
  DOI: 10.1093/chemse/bjs055

• The role of octopamine and tyramine in Drosophila larval locomotion
  Selcho M, Pauls D, El Jundi B, Stocker RF, Thum AS.
  J Comp Neurol. 2012 Nov 1;520(16):3764-85.
  DOI: 10.1002/cne.23152

• Capacity of visual classical conditioning in Drosophila larvae
  von Essen AM, Pauls D, Thum AS, Sprecher SG.
  Behav Neurosci. 2011 Dec;125(6):921-9.
  DOI: 10.1037/a0025758

• Diversity, variability, and suboesophageal connectivity of antennal lobe neurons in D. melanogaster larvae
  Thum AS, Leisibach B, Gendre N, Selcho M, Stocker RF.
  J Comp Neurol. 2011 Dec 1;519(17):3415-32.
  DOI: 10.1002/cne.22713

• Effects of chlorinated acetates on the glutathione metabolism and on glycolysis of cultured astrocytes
  Schmidt MM, Rohwedder A, Dringen R.
  Neurotox Res. 2011 May;19(4):628-37.
  DOI: 10.1007/s12640-010-9209-8

• Drosophila larvae establish appetitive olfactory memories via mushroom body neurons of embryonic origin
  Pauls D, Selcho M, Gendre N, Stocker RF, Thum AS.
  J Neurosci. 2010 Aug 11;30(32):10655-66.
  DOI: 10.1523/JNEUROSCI.1281-10.2010

• Electric shock-induced associative olfactory learning in Drosophila larvae
  Pauls D, Pfitzenmaier JE, Krebs-Wheaton R, Selcho M, Stocker RF, Thum AS.
  Chem Senses. 2010 May;35(4):335-46.
  DOI: 10.1093/chemse/bjq023

2009 und früher

• The role of dopamine in Drosophila larval classical olfactory conditioning
  Selcho M, Pauls D, Han KA, Stocker RF, Thum AS.
  PLoS One. 2009 Jun 12;4(6):e5897.
  DOI: 10.1371/journal.pone.0005897

• Smelling, tasting, learning: Drosophila as a study case
  Gerber B, Stocker RF, Tanimura T, Thum AS.
  Results Probl Cell Differ. 2009;47:139-85.
  DOI: 10.1007/400_2008_9

• The neural substrate of spectral preference in Drosophila
  Gao S, Takemura SY, Ting CY, Huang S, Lu Z, Luan H, Rister J, Thum AS, Yang M, Hong ST, Wang JW, Odenwald WF, White BH, Meinertzhagen IA, Lee CH.
  Neuron. 2008 Oct 23;60(2):328-42.
  DOI: 10.1016/j.neuron.2008.08.010

• Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse
  Pantazis A, Segaran A, Liu CH, Nikolaev A, Rister J, Thum AS, Roeder T, Semenov E, Juusola M, Hardie RC.
  J Neurosci. 2008 Jul 16;28(29):7250-9.
  DOI: 10.1523/JNEUROSCI.1654-08.2008

• Multiple memory traces for olfactory reward learning in Drosophila
  Thum AS, Jenett A, Ito K, Heisenberg M, Tanimoto H.
  J Neurosci. 2007 Oct 10;27(41):11132-8.
  DOI: 10.1523/JNEUROSCI.2712-07.2007

• Differential potencies of effector genes in adult Drosophila
  Thum AS, Knapek S, Rister J, Dierichs-Schmitt E, Heisenberg M, Tanimoto H.
  J Comp Neurol. 2006 Sep 10;498(2):194-203.
  DOI: 10.1002/cne.21022

• Relations in biomedical ontologies
  Smith B, Ceusters W, Klagges B, Köhler J, Kumar A, Lomax J, Mungall C, Neuhaus F, Rector AL, Rosse C.
  Genome Biol. 2005;6(5):R46.
  DOI: 10.1186/gb-2005-6-5-r46

• Flies lacking all synapsins are unexpectedly healthy but are impaired in complex behaviour
  Godenschwege TA, Reisch D, Diegelmann S, Eberle K, Funk N, Heisenberg M, Hoppe V, Hoppe J, Klagges BR, Martin JR, Nikitina EA, Putz G, Reifegerste R, Reisch N, Rister J, Schaupp M, Scholz H, Schwärzel M, Werner U, Zars TD, Buchner S, Buchner E.
  Eur J Neurosci. 2004 Aug;20(3):611-22.
  DOI: 10.1111/j.1460-9568.2004.03527.x

• Invertebrate synapsins: a single gene codes for several isoforms in Drosophila
  Klagges BR, Heimbeck G, Godenschwege TA, Hofbauer A, Pflugfelder GO, Reifegerste R, Reisch D, Schaupp M, Buchner S, Buchner E.
  J Neurosci. 1996 May 15;16(10):3154-65.
  DOI: 10.1523/JNEUROSCI.16-10-03154.1996

• The sap47 gene of Drosophila melanogaster codes for a novel conserved neuronal protein associated with synaptic terminals
  Reichmuth C, Becker S, Benz M, Debel K, Reisch D, Heimbeck G, Hofbauer A, Klagges B, Pflugfelder GO, Buchner E.
  Brain Res Mol Brain Res. 1995 Aug;32(1):45-54.
  DOI: 10.1016/0169-328x(95)00058-z