Dr. Raimund Nagel

Dr. Raimund Nagel

Research Fellow

Johannisallee 23, Room 104
04103 Leipzig

Telephone: +49 341-9738524

Short profile

Raimund Nagel is a group leader in the department Plant Physiology at the Insitute of Biology. He is teaching plant physiology and investigates the secondary metabolism of plants and plant-associated bacteria, in particular the production of gibberellins in phytopathogenic bacteria. The aim of this research is to better understand how bacteria circumvent the plant's pathogenic defence and how plants synthesize secondary metabolites to defend against pathogens and herbivores.

  • Since 2019

    Group leader in the department of Prof. Severin Sasso at the University of Leipzig (Germany)

  • 2014 - 2019

    Postdoctoral Researcher in the group of Prof. Reuben Peters at the Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, (USA), funded by Deutsche Forschungsgemeinschaft (2016 – 2018)

  • 2010 - 2014

    Ph.D. student and postdoctoral fellow at the Max-Planck-Institute for Chemical Ecology in the Biochemistry Department of Prof. Jonathan Gershenzon

  • 2004 - 2010

    Undergraduate studies in biochemistry at the Friedrich-Schiller-Universität Jena (Germany)

  • Nagel, R. (2019)
    Pyrethrin biosynthesis: From a phytohormone to specialized metabolite.
    Plant Physiology. 181:836–837.
  • Lackus, N. D.; Petersen, N. P.; Nagel, R.; Schmidt, A.; Irmisch, S.; Gershenzon, J.; Köllner, T. G.   (2019)
    Identification and characterization of trans-Isopentenyl diphosphate synthases involved in herbivory-induced volatile terpene formation in Populus trichocarpa.
    Molecules. 24:2408.
  • Nagel, R.; Schmidt, A.; Peters, R. J. (2019)
    Isoprenyl diphosphate synthases: the chain length determining step in terpene biosynthesis.
    Planta. 249:9–20. 
  • Nagel R, Bieber JE, Schmidt-Dannert MG, Nett RS, Peters RJ (2018)
    A third class: Functional gibberellin biosynthetic operon in beta-Proteobacteria.
    Front. Microbiol. 9
  • Nagel R, Peters R (2018)
    Probing the specificity of CYP112 in bacterial gibberellin biosynthesis.
    Biochemical Journal 475:2167–2177
  • Nagel R, Peters RJ (2018)
    Diverging Mechanisms: Cytochrome-P450-catalyzed demethylation and γ-lactone formation in bacterial gibberellin biosynthesis.
    Angewandte Chemie 130:6190–6193
  • Nagel R, Thomas JA, Adekunle FA, Mann FM, Peters RJ (2018)
    Arginine in the FARM and SARM: A role in chain-length determination for arginine in the aspartate-rich motifs of isoprenyl diphosphate synthases from Mycobacterium tuberculosis.
    Molecules 23:2546
  • Nagel R, J. Peters R (2017)
    18O2 labeling experiments illuminate the oxidation of ent-aurene in bacterial gibberellin biosynthesis.
    Organic & Biomolecular Chemistry 15:7566–7571
  • Nagel R, Peters RJ (2017)
    Investigating the phylogenetic range of gibberellin biosynthesis in bacteria.
    MPMI 30:343–349
  • Nagel R1), Turrini PCG1), Nett RS, Leach JE, Verdier V, Sluys M-AV, Peters RJ (2017)
    An operon for production of bioactive gibberellin A4 phytohormone with wide distribution in the bacterial rice leaf streak pathogen Xanthomonas oryzae pv. oryzicola.
    New Phytologist 214:1260–1266
  • Nett RS, Montanares M, Marcassa A, Lu X, Nagel R, Charles TC, Hedden P, Rojas MC, Peters RJ (2017)
    Elucidation of gibberellin biosynthesis in bacteria reveals convergent evolution.
    Nat Chem Biol 13:69–74
  • Kortbeek RWJ, Xu J, Ramirez A, Spyropoulou E, Diergaarde P, Otten-Bruggeman I, de Both M, Nagel R, Schmidt A, Schuurink RC, Bleeker PM (2016)
    Engineering of Tomato glandular trichomes for the production of specialized metabolites.
    In: O’Connor SE, editor(s). Methods in Enzymology. Academic Press; p. 305–331.
  • Beran F, Rahfeld P, Luck K, Nagel R, Vogel H, Wielsch N, Irmisch S, Ramasamy S, Gershenzon J, Heckel DG, Köllner TG (2016)
    Novel family of terpene synthases evolved from trans-isoprenyl diphosphate synthases in a flea beetle.
    PNAS 113:2922–2927
  • Nagel R, Bernholz C, Vranová E, Košuth J, Bergau N, Ludwig S, Wessjohann L, Gershenzon J, Tissier A, Schmidt A (2015)
    Arabidopsis thaliana isoprenyl diphosphate synthases produce the C25 intermediate geranylfarnesyl diphosphate.
    The Plant Journal 84:847–859
  • Nagel R, Berasategui A, Paetz C, Gershenzon J, Schmidt A (2014)
    Overexpression of an isoprenyl diphosphate synthase in Spruce leads to unexpected terpene diversion products that function in plant defense. Plant Physiology 164:555–569
  • Frick S, Nagel R, Schmidt A, Bodemann RR, Rahfeld P, Pauls G, Brandt W, Gershenzon J, Boland W, Burse A (2013)
    Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway. PNAS 110:4194–4199
  • Kulkarni R, Pandit S, Chidley H, Nagel R, Schmidt A, Gershenzon J, Pujari K, Giri A, Gupta V (2013)
    Characterization of three novel isoprenyl diphosphate synthases from the terpenoid rich mango fruit. Plant Physiology and Biochemistry 71:121–131
  • Nagel R, Gershenzon J, Schmidt A (2012)
    Nonradioactive assay for detecting isoprenyl diphosphate synthase activity in crude plant extracts using liquid chromatography coupled with tandem mass spectrometry. Analytical Biochemistry 422:33–38
  • Schmidt A, Nagel R, Krekling T, Christiansen E, Gershenzon J, Krokene P (2011)
    Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies). Plant Mol Biol 77:577–590


1) gleiche Beiträge
2) geteilte Korrespondenzautorschaft

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