Transfer RNAs (tRNAs) are structurally highly conserved molecules that act as key players in protein biosynthesis.

They form a typical ‘cloverleaf’ secondary fold consisting of four stem and stem-loop structures, respectively. Tertiary interactions allow the tRNA to fold into its functional L-shaped three-dimensional structure

Among all transcripts, tRNAs show the highest density and variety of post-transcriptional modifications. Such base and ribose alterations play a major role in decoding as well as structural stabilization. One of our research interests is the impact of modifications on the structure of aberrant and bizarre tRNAs.

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