Champion (Eichler) - Connectomics

2024

• Network statistics of the whole-brain connectome of Drosophila
  Lin A, Yang R, Dorkenwald S, Matsliah A, Sterling AR, Schlegel P, Yu SC, McKellar CE, Costa M, Eichler K, Bates AS, Eckstein N, Funke J, Jefferis GSXE, Murthy M.
  Nature. 2024 Oct;634(8032):153-165.
  DOI: 10.1038/s41586-024-07968-y  

• The fly connectome reveals a path to the effectome.
  Pospisil DA, Aragon MJ, Dorkenwald S, Matsliah A, Sterling AR, Schlegel P, Yu SC, McKellar CE, Costa M, Eichler K, Jefferis GSXE, Murthy M, Pillow JW.
  Nature. 2024 Oct;634(8032):201-209.
  DOI: 10.1038/s41586-024-07982-0.

• Whole-brain annotation and multi-connectome cell typing of Drosophila.
  Schlegel P, Yin Y, Bates AS, Dorkenwald S, Eichler K, Brooks P, Han DS, Gkantia M, Dos Santos M, Munnelly EJ, Badalamente G, Serratosa Capdevila L, Sane VA, Fragniere AMC, Kiassat L, Pleijzier MW, Stürner T, Tamimi IFM, Dunne CR, Salgarella I, Javier A, Fang S, Perlman E, Kazimiers T, Jagannathan SR, Matsliah A, Sterling AR, Yu SC, McKellar CE; FlyWire Consortium; Costa M, Seung HS, Murthy M, Hartenstein V, Bock DD, Jefferis GSXE.
  Nature. 2024 Oct;634(8032):139-152.
  DOI: 10.1038/s41586-024-07686-5

• Neural circuit mechanisms underlying context-specific halting in Drosophila.
  Sapkal N, Mancini N, Kumar DS, Spiller N, Murakami K, Vitelli G, Bargeron B, Maier K, Eichler K, Jefferis GSXE, Shiu PK, Sterne GR, Bidaye SS.
  Nature. 2024 Oct;634(8032):191-200.
  DOI: 10.1038/s41586-024-07854-7

• A Drosophila computational brain model reveals sensorimotor processing.
  Shiu PK, Sterne GR, Spiller N, Franconville R, Sandoval A, Zhou J, Simha N, Kang CH, Yu S, Kim JS, Dorkenwald S, Matsliah A, Schlegel P, Yu SC, McKellar CE, Sterling A, Costa M, Eichler K, Bates AS, Eckstein N, Funke J, Jefferis GSXE, Murthy M, Bidaye SS, Hampel S, Seeds AM, Scott K.
  Nature. 2024 Oct;634(8032):210-219
  DOI: 10.1038/s41586-024-07763-9

• Neuronal wiring diagram of an adult brain.
  Dorkenwald S, Matsliah A, Sterling AR, Schlegel P, Yu SC, McKellar CE, Lin A, Costa M, Eichler K, Yin Y, Silversmith W, Schneider-Mizell C, Jordan CS, Brittain D, Halageri A, Kuehner K, Ogedengbe O, Morey R, Gager J, Kruk K, Perlman E, Yang R, Deutsch D, Bland D, Sorek M, Lu R, Macrina T, Lee K, Bae JA, Mu S, Nehoran B, Mitchell E, Popovych S, Wu J, Jia Z, Castro MA, Kemnitz N, Ih D, Bates AS, Eckstein N, Funke J, Collman F, Bock DD, Jefferis GSXE, Seung HS, Murthy M; FlyWire Consortium.
  Nature. 2024 Oct;634(8032):124-138
  DOI: 10.1038/s41586-024-07558-y

• Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster.
  Eckstein N, Bates AS, Champion A, Du M, Yin Y, Schlegel P, Lu AK, Rymer T, Finley-May S, Paterson T, Parekh R, Dorkenwald S, Matsliah A, Yu SC, McKellar C, Sterling A, Eichler K, Costa M, Seung S, Murthy M, Hartenstein V, Jefferis GSXE, Funke J.
  Cell. 2024 May 9;187(10):2574-2594.e23.
  DOI: 10.1016/j.cell.2024.03.016

• Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila. 
  Eichler K, Hampel S, Alejandro-García A, Calle-Schuler SA, Santana-Cruz A, Kmecova L, Blagburn JM, Hoopfer ED, Seeds AM.
  Elife. 2024 Apr 18;12:RP87602.
  DOI: 10.7554/eLife.87602

   

   

2019 – 2023

• Rewarding Capacity of Optogenetically Activating a Giant GABAergic Central-Brain Interneuron in Larval Drosophila. 
  Mancini N, Thoener J, Tafani E, Pauls D, Mayseless O, Strauch M, Eichler K, Champion A, Kobler O, Weber D, Sen E, Weiglein A, Hartenstein V, Chytoudis-Peroudis CC, Jovanic T, Thum AS, Rohwedder A, Schleyer M, Gerber B.
  J Neurosci. 2023 Nov 1;43(44):7393-7428.
  DOI: 10.1523/JNEUROSCI.2310-22.2023

• Circuits for integrating learned and innate valences in the insect brain.
  Eschbach C, Fushiki A, Winding M, Afonso B, Andrade IV, Cocanougher BT, Eichler K, Gepner R, Si G, Valdes-Aleman J, Fetter RD, Gershow M, Jefferis GS, Samuel AD, Truman JW, Cardona A, Zlatic M.
  Elife. 2021 Nov 10;10:e62567.
  DOI: 10.7554/eLife.62567

• Distinct subpopulations of mechanosensory chordotonal organ neurons elicit grooming of the fruit fly antennae.
  Hampel S, Eichler K, Yamada D, Bock DD, Kamikouchi A, Seeds AM.
  Elife. 2020 Oct 26;9:e59976.
  DOI: 10.7554/eLife.59976

• Identification of Dopaminergic Neurons That Can Both Establish Associative Memory and Acutely Terminate Its Behavioral Expression.
  Schleyer M, Weiglein A, Thoener J, Strauch M, Hartenstein V, Kantar Weigelt M, Schuller S, Saumweber T, Eichler K, Rohwedder A, Merhof D, Zlatic M, Thum AS, Gerber B.
  J Neurosci. 2020 Jul 29;40(31):5990-6006.
  DOI: 10.1523/JNEUROSCI.0290-20.2020

• Recurrent architecture for adaptive regulation of learning in the insect brain.
  Eschbach C, Fushiki A, Winding M, Schneider-Mizell CM, Shao M, Arruda R, Eichler K, Valdes-Aleman J, Ohyama T, Thum AS, Gerber B, Fetter RD, Truman JW, Litwin-Kumar A, Cardona A, Zlatic M.
  Nat Neurosci. 2020 Apr;23(4):544-555.
  DOI: 10.1038/s41593-020-0607-9

• Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila 
  Saumweber T, Rohwedder A, Schleyer M, Eichler K, Chen YC, Aso Y, Cardona A, Eschbach C, Kobler O, Voigt A, Durairaja A, Mancini N, Zlatic M, Truman JW, Thum AS, Gerber B.
  Nat Commun. 2018 Mar 16;9(1):1104.
  DOI: 10.1038/s41467-018-03130-1

• Odor-taste learning in Drosophila larvae 
  Widmann A, Eichler K, Selcho M, Thum AS, Pauls D. 
  J Insect Physiol. 2018 Apr;106(Pt 1):47-54.
  DOI: 10.1016/j.jinsphys.2017.08.004

• The complete connectome of a learning and memory centre in an insect brain.
  Eichler K, Li F, Litwin-Kumar A, Park Y, Andrade I, Schneider-Mizell CM, Saumweber T, Huser A, Eschbach C, Gerber B, Fetter RD, Truman JW, Priebe CE, Abbott LF, Thum AS, Zlatic M, Cardona A. 
  Nature. 2017 Aug 9;548(7666):175-182.
  DOI: 10.1038/nature23455

• The Ol1mpiad: concordance of behavioural faculties of stage 1 and stage 3 Drosophila larvae.
  Almeida-Carvalho MJ, Berh D, Braun A, Chen YC, Eichler K, Eschbach C, Fritsch PMJ, Gerber B, Hoyer N, Jiang X, Kleber J, Klämbt C, König C, Louis M, Michels B, Miroschnikow A, Mirth C, Miura D, Niewalda T, Otto N, Paisios E, Pankratz MJ, Petersen M, Ramsperger N, Randel N, Risse B, Saumweber T, Schlegel P, Schleyer M, Soba P, Sprecher SG, Tanimura T, Thum AS, Toshima N, Truman JW, Yarali A, Zlatic M. 
  J Exp Biol. 2017 Jul 1;220(Pt 13):2452-2475.
  DOI: 10.1242/jeb.156646

 

2019 – 2023

• Rewarding Capacity of Optogenetically Activating a Giant GABAergic Central-Brain Interneuron in Larval Drosophila. 
  Mancini N, Thoener J, Tafani E, Pauls D, Mayseless O, Strauch M, Eichler K, Champion A, Kobler O, Weber D, Sen E, Weiglein A, Hartenstein V, Chytoudis-Peroudis CC, Jovanic T, Thum AS, Rohwedder A, Schleyer M, Gerber B.
  J Neurosci. 2023 Nov 1;43(44):7393-7428.
  DOI: 10.1523/JNEUROSCI.2310-22.2023

• Circuits for integrating learned and innate valences in the insect brain.
  Eschbach C, Fushiki A, Winding M, Afonso B, Andrade IV, Cocanougher BT, Eichler K, Gepner R, Si G, Valdes-Aleman J, Fetter RD, Gershow M, Jefferis GS, Samuel AD, Truman JW, Cardona A, Zlatic M.
  Elife. 2021 Nov 10;10:e62567.
  DOI: 10.7554/eLife.62567

• Distinct subpopulations of mechanosensory chordotonal organ neurons elicit grooming of the fruit fly antennae.
  Hampel S, Eichler K, Yamada D, Bock DD, Kamikouchi A, Seeds AM.
  Elife. 2020 Oct 26;9:e59976.
  DOI: 10.7554/eLife.59976

• Identification of Dopaminergic Neurons That Can Both Establish Associative Memory and Acutely Terminate Its Behavioral Expression.
  Schleyer M, Weiglein A, Thoener J, Strauch M, Hartenstein V, Kantar Weigelt M, Schuller S, Saumweber T, Eichler K, Rohwedder A, Merhof D, Zlatic M, Thum AS, Gerber B.
  J Neurosci. 2020 Jul 29;40(31):5990-6006.
  DOI: 10.1523/JNEUROSCI.0290-20.2020

• Recurrent architecture for adaptive regulation of learning in the insect brain.
  Eschbach C, Fushiki A, Winding M, Schneider-Mizell CM, Shao M, Arruda R, Eichler K, Valdes-Aleman J, Ohyama T, Thum AS, Gerber B, Fetter RD, Truman JW, Litwin-Kumar A, Cardona A, Zlatic M.
  Nat Neurosci. 2020 Apr;23(4):544-555.
  DOI: 10.1038/s41593-020-0607-9

• Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila 
  Saumweber T, Rohwedder A, Schleyer M, Eichler K, Chen YC, Aso Y, Cardona A, Eschbach C, Kobler O, Voigt A, Durairaja A, Mancini N, Zlatic M, Truman JW, Thum AS, Gerber B.
  Nat Commun. 2018 Mar 16;9(1):1104.
  DOI: 10.1038/s41467-018-03130-1

• Odor-taste learning in Drosophila larvae 
  Widmann A, Eichler K, Selcho M, Thum AS, Pauls D. 
  J Insect Physiol. 2018 Apr;106(Pt 1):47-54.
  DOI: 10.1016/j.jinsphys.2017.08.004

• The complete connectome of a learning and memory centre in an insect brain.
  Eichler K, Li F, Litwin-Kumar A, Park Y, Andrade I, Schneider-Mizell CM, Saumweber T, Huser A, Eschbach C, Gerber B, Fetter RD, Truman JW, Priebe CE, Abbott LF, Thum AS, Zlatic M, Cardona A. 
  Nature. 2017 Aug 9;548(7666):175-182.
  DOI: 10.1038/nature23455

• The Ol1mpiad: concordance of behavioural faculties of stage 1 and stage 3 Drosophila larvae.
  Almeida-Carvalho MJ, Berh D, Braun A, Chen YC, Eichler K, Eschbach C, Fritsch PMJ, Gerber B, Hoyer N, Jiang X, Kleber J, Klämbt C, König C, Louis M, Michels B, Miroschnikow A, Mirth C, Miura D, Niewalda T, Otto N, Paisios E, Pankratz MJ, Petersen M, Ramsperger N, Randel N, Risse B, Saumweber T, Schlegel P, Schleyer M, Soba P, Sprecher SG, Tanimura T, Thum AS, Toshima N, Truman JW, Yarali A, Zlatic M. 
  J Exp Biol. 2017 Jul 1;220(Pt 13):2452-2475.
  DOI: 10.1242/jeb.156646

 

2018 and earlier

• Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila 
  Saumweber T, Rohwedder A, Schleyer M, Eichler K, Chen YC, Aso Y, Cardona A, Eschbach C, Kobler O, Voigt A, Durairaja A, Mancini N, Zlatic M, Truman JW, Thum AS, Gerber B. 
  Nat Commun. 2018 Mar 16;9(1):1104.
  DOI: 10.1038/s41467-018-03130-1

• Odor-taste learning in Drosophila larvae
  Widmann A, Eichler K, Selcho M, Thum AS, Pauls D.
  J Insect Physiol. 2018 Apr;106(Pt 1):47-54.
  DOI: 10.1016/j.jinsphys.2017.08.004

• The complete connectome of a learning and memory centre in an insect brain.
  Eichler K, Li F, Litwin-Kumar A, Park Y, Andrade I, Schneider-Mizell CM, Saumweber T, Huser A, Eschbach C, Gerber B, Fetter RD, Truman JW, Priebe CE, Abbott LF, Thum AS, Zlatic M, Cardona A.
  Nature. 2017 Aug 9;548(7666):175-182.
  DOI: 10.1038/nature23455

• The Ol1mpiad: concordance of behavioural faculties of stage 1 and stage 3 Drosophila larvae.
  Almeida-Carvalho MJ, Berh D, Braun A, Chen YC, Eichler K, Eschbach C, Fritsch PMJ, Gerber B, Hoyer N, Jiang X, Kleber J, Klämbt C, König C, Louis M, Michels B, Miroschnikow A, Mirth C, Miura D, Niewalda T, Otto N, Paisios E, Pankratz MJ, Petersen M, Ramsperger N, Randel N, Risse B, Saumweber T, Schlegel P, Schleyer M, Soba P, Sprecher SG, Tanimura T, Thum AS, Toshima N, Truman JW, Yarali A, Zlatic M.
  J Exp Biol. 2017 Jul 1;220(Pt 13):2452-2475.
  DOI: 10.1242/jeb.156646

• Immediate and punitive impact of mechanosensory disturbance on olfactory behaviour of larval Drosophila. 
  Saumweber T, Cano C, Klessen J, Eichler K, Fendt M, Gerber B.
  Biol Open. 2014 Sep 26;3(10):1005-10.
  DOI: 10.1242/bio.20149183