Collaborative Research Centre 610 CRC/ Transregio 67  

Along with other institutions, the Faculty of Life Sciences has been selected to administer two projects of the Collaborative Research Centre (CRC) and CRC/ Transregio programmes funded by the German Research Foundation DFG (Deutsche Forschungsgemeinschaft):


Collaborative Research Centre 610 (CRC 610)

The CRC 610 on “Variation in Protein Conformation: Cell-biological and Pathological Relevance” is managed by the University of Leipzig, the Martin Luther University Halle-Wittenberg and the Max Planck Research Unit for Enzymology of Protein Folding in Halle (Saale). Established in 2002, the CRC 610 continues to receive funding and is now in its third funding period. Its coordinator at the University of Leipzig is Prof. Dr. Annette Beck-Sickinger.

The CRC 610 deals with relevant examples of protein folding states and their impact on the evolution of disease patterns. There is an ever greater understanding of the relevance of variations in protein conformation, such as varying folding states, in terms of issues pertaining to cell biology and medicine. Among other diseases, protein folding is known to impact Creutzfeldt-Jakob disease and cystic fibrosis. Still mostly unknown to scientists is the impact of such variations in protein folding states on the biological functions of proteins at the molecular level.

The CRC 610 is divided into three research areas dealing with the “Characterization of functionally relevant Protein Conformations”, the “Variation in Protein Conformation and Strategies of Intervention” and the “Characterization of functionally relevant Protein Modifications”. Furthermore, a transfer project carried out in alliance with the industry seeks to utilise the results of previous research conducted in the CRC 610.
The Integrated Research Training Group “Protein Science” specialises in facilitating further qualification of junior researchers participating in CRC 610 and the networking between the doctoral students of the project’s research areas.

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CRC/ Transregio 67

The important successes in implantation and transplantation medicine achieved over the last years were mainly based on the increase in experimental knowledge. The CRC/ Transregio 67 research project on “Functional Biomaterials for Controlling Healing Processes in Bone and Skin – from Material Science to Clinical Application” seeks to take on a radically different approach and advance the knowledge and understanding and further development of artificial extracellular matrices (aECM) for wound healing in skin and bone injuries by focusing on basic research. The CRC/ Transregio 67 consists of the following two research areas:

Research Area A – Matrix Engineering – is comprised of projects that put their main emphasis on materials science and chemistry; it also includes projects concerned with analytical issues.

Research Area B – Biologically active profiles in cell systems and aECM-based tissue regeneration – combines projects with a cell-biological and clinical focus. Hereby, the main emphasis is placed on the systematic cell and molecular-biological characterization of matrix/cell interactions in complex systems.

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last update: 29.09.2017