Center of Molecular Interactions in Biomedicine and Biotechnology  


Mission

The faculty based Center for Molecular Interactions in Biomedicine and Biotechnology investigates how molecules, cells and cell structures interact. Insight into these dynamics represents the core of life sciences and allows to translate them into biotechnology and biomedicine.

Research environment

The Centre constitutes an integral element of the University's research profile areas „Complex Matter“ and „Molecular and Cellular Communication in Therapy and Diagnostics“ and maintains fruitful cooperations with the Faculty of Chemistry and Mineralogy and the Faculty of Physics and Earth Sciences. Once the Institute of Pharmacy was transferred to the Faculty of Medicine ties with the latter have become even closer. Most research groups of this Centre are members of the Center for Biotechnology and Biomedicine (BBZ) as well. Professorships involved in the Centre enjoy cooperations with extra-faculty institutions in Leipzig. Among these are the Helmholtz Centre for Environmental Research, the Helmholz Institute of Metabolic, Obesity and Vascular Research, the Leibniz Institute of Surface Engineering and the Fraunhofer Institute of Cell Therapy and Immunology.

Focus Topics

Biocatalysis and cell reactors and their uses in biotechnology

This topic focuses on how to develop novel enzymes, bioprocesses and enzyme-substrate complexes and how to better understand enzyme-substrate interactions. We also try to biochemically modify enzymes, enzyme complexes, microbial cells and cell clusters in such a way they become available for biotechnological applications.

 
Biosensors and biomaterials

Projects belonging to this focus topic deal with the synthesis of new materials. Also, we endeavor to modify surfaces on the basis of synthetic and natural polymers and bioorganic molecules. This will lead to novel sensor and analysis tools and methods that find application in biomedical and biotechnological technologies as well as in environmental research. We also create biomimetical cell culture carriers and drug delivery systems for in vitro and in vivo usage.

 
Transmembrane receptors, cytoskeleton and their signal transduction

Yet another group of projects takes a closer look at transmembrane receptors and cell adhesion structures. These communicate and interact with cells and tissues and the inner cell. Our researchers characterize the underlying dynamics and create tools to better analyze and describe them. They also investigate how membrane receptors impact a cell's response to external stimuli both under normal and pathological conditions. Insight on currently used drugs is implemented in the development of novel drugs and therapies.

 
Chemical modification of peptides, RNAs and proteins

Mid-sized components, i.e. peptides, small proteins and ribonucleic acid, are another object of or our research. They bridge the gap between small - and mainly chemically generated - molecules and antibodies. Researchers generate these mid-sized components using biological and bioorganical methods, and then charactereize and stabilize them for biotechnological and biomedical studies. Mid-sized drugs are also valuable tools for understanding biological processes: they can be coupled with probes that enable biophysical research.

Outlook

Translation into English: work in progress

Das Zentrum für Molekulare Wechselwirkungen in Biomedizin und Biotechnologie ist aktuell mit seinen Forschungsarbeiten an zahlreichen größeren Forschungsverbünden und sonderforschungsbereichen beteiligt (z.B. SFB-TR67, SFB 1052, DFG FOR 2177 InCheM, SPP 1782, SPP 1782, SPP 1623, Wachstumskern BioSAM, BMBF-BioÖkonomie2030, P4SB-Horizon2020). Auch in Zukunft werden die Arbeitsgruppen aktiv an der Etablierung neuer Forschungsverbünde mitwirken.


last update: 15.04.2021 

Center of Molecular Interactions in Biomedicine and Biotechnology

Acting Directorate

Professor Annette Beck-Sickinger
Institute of Biochemistry
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Professor Mario Mörl
Institute of Biochemistry
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Professor Tilo Pompe
Institute of Biochemistry
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